Perinorm: Uses and Side Effects
Perinorm Tablet is commonly used to manage gastrointestinal issues such as nausea and vomiting in patients with gastroesophageal reflux disease and diabetic gastroparesis. Perinorm Tablet also provides relief from symptoms associated with conditions like indigestion and heartburn. It contains metoclopramide hydrochloride (10 mg) that helps regulate the movement of the stomach and intestines. The medication works by increasing the contractions of the stomach and intestines, aiding food movement through the digestive tract.
What is the Perinorm Tablet used for?
Perinorm uses include the following:
- Diabetic Gastroparesis (diabetic gastric stasis): Diabetic Gastroparesis, also known as Diabetic Gastric Stasis, is a condition where delayed stomach emptying occurs in individuals with diabetes. The symptoms include persistent nausea, vomiting, bloating, abdominal pain, and a feeling of fullness. It results from damage to the vagus nerve, which controls the muscles of the stomach. Perinorm Tablet helps by increasing stomach motility, aiding in better digestion and reducing symptoms like nausea and vomiting associated with gastroparesis.
- Gastroesophageal reflux disease (GERD): It is a chronic condition where stomach acid flows back into the oesophagus, causing heartburn and irritation. Perinorm Tablet helps reduce symptoms by enhancing stomach emptying and reducing the likelihood of acid reflux.
How does Perinorm Tablet work?
Perinorm Tablet contains metoclopramide hydrochloride, a prokinetic agent that enhances stomach and intestine motility, improving gastric emptying and reducing nausea and vomiting. The medication achieves this by blocking dopamine receptors in the brain and gastrointestinal tract. Dopamine, a neurotransmitter, influences movement and coordination. By inhibiting dopamine receptors, metoclopramide hydrochloride boosts the release of acetylcholine, another neurotransmitter that stimulates smooth muscle contraction in the gastrointestinal tract.
How to take Perinorm Tablet dose?
Perinorm Tablet dosage should be taken as directed by your doctor. Generally, it is advisable to take the medication 30 minutes before each meal and at bedtime for 4 to 12 weeks. The recommended dose for adults is one tablet three to four times daily. However, it’s crucial to follow the specific instructions provided by your doctor based on your individual medical condition and needs. Swallow the tablet with a glass of water, and do not crush or chew. If you have any concerns or questions about the dosage, consult your doctor.
Are there any side effects of taking a Perinorm Tablet?
Perinorm Tablet can potentially cause certain side effects. These commonly include:
- Restlessness
- Drowsiness
- Tiredness
- Lack of energy
- High blood pressure
- Missed menstrual period
- Enlarged breasts
- Decreased sexual ability
- Frequent urination
If any of these side effects persist or worsen, you should seek guidance from your doctor. This tablet can also make you feel depressed. Speak to your doctor if you experience depression after taking this tablet.
What happens if an excess of Perinorm Tablets are taken at once?
Taking too much Perinorm Tablet can lead to severe symptoms such as high fever, muscle stiffness, changes in mental alertness, and signs of autonomic instability like irregular pulse or blood pressure, rapid heart rate, sweating, and heart rhythm issues. Other signs may include increased creatine phosphokinase, myoglobin in the urine (rhabdomyolysis), and sudden kidney failure. If you experience these symptoms, seek immediate medical attention. It’s important not to exceed the prescribed dose to avoid these severe side effects.
Is Perinorm Tablet safe during pregnancy?
The use of Perinorm Tablet during pregnancy should be done with caution. It is crucial to consult with your doctor before taking this medication if you are pregnant or planning to become pregnant. This cautious approach is essential to ensure the well-being of the expectant mother and the developing foetus. Your doctor may suggest other safe medications for GERD or diabetic gastroparesis during pregnancy.
Can Perinorm Tablets be given to children?
Perinorm Tablets are recommended for children. These tablets may increase the risk of developing certain movement-related issues like tardive dyskinesia (TD). It is a condition characterised by involuntary, repetitive movements of the face, tongue, or other body parts. There is also a risk of developing other symptoms affecting body movements.
What are the safety precautions when using Perinorm Tablet?
Follow these precautions for the safe use of Perinorm Tablet:
- Elder patients: Older adults with kidney impairment should cautiously take this tablet. Dosage reduction may be required in older adults.
- Alcohol: Avoid alcohol while taking Perinorm Tablets strictly. Alcohol can add to the central nervous system side effects of Perinorm Tablet.
- History of tardive dyskinesia (TD): Perinorm Tablet should be used cautiously in individuals with tardive dyskinesia (TD). It may increase the risk or worsen symptoms of TD.
- Diabetes: Patients with diabetes should also cautiously take this tablet due to the increased risk of tardive dyskinesia (TD).
- Pheochromocytoma or other catecholamine-releasing paragangliomas: Caution is advised in individuals with pheochromocytoma or other catecholamine-releasing paragangliomas. Perinorm may stimulate the release of catecholamines, leading to a sudden surge in blood pressure.
- Epilepsy: In patients with epilepsy, this medication may lower the seizure threshold. Close monitoring is required to ensure that Perinorm does not trigger seizures or worsen the existing condition.
- Neuroleptic malignant syndrome (NMS): It is a neurological condition that arises due to the use of antipsychotic medications. Those with a history of neuroleptic malignant syndrome (NMS) should use Perinorm cautiously. It is a rare but serious reaction to certain medications.
- Hypertension: Caution is warranted in patients with hypertension (high blood pressure) when using Perinorm. This tablet may increase the blood pressure and worsen the condition.
- Parkinsonism: Perinorm should be used cautiously in individuals with Parkinsonism. While the medication may be used to manage certain symptoms, its effects on neurotransmitters may interact with Parkinsonism and aggravate the condition.
Which medicines should you avoid when taking a Perinorm Tablet?
If you take other medication simultaneously with Perinorm Tablet, please consult your doctor. After getting a consultation from the doctor you can get these medicines online easily. Do not take Antipsychotics, quinidine, bupropion, fluoxetine, paroxetine, hypnotics, opiates, antidepressants and medications that increase dopamine concentrations with this tablet. These medications may alter the safety and effectiveness of Perinorm Tablet. If you take insulin to manage your blood sugar levels, consult your doctor to avoid any adverse effects.
